Studies on Electrode Kinetics of Mixed Legand Complexes of Mn (11) In Dioxan At DME.

Mixed ligand complexes of Mn (11) with pyridines and halides and pseudohalides have been synthesised. The reduction of synthesised complexes at dropping mercury electrode in various percentage of dioxan have been studied. The reductions are diffusion controlled. Slope values indicate reduction to be irrversible. Kinetic parameters [K0 fh,αn &ε] have been calculated by Meites Isreal and Gaur Bhargava Methods. The effects of various compositions of dioxan have been investigated.

Novel Eco-Friendly Approaches for the Reduction of Selected Carbonyl Compounds.

This paper reports reduction of (-)-verbenone, 1,3-indanedione, 3-indolyl methyl ketone and 2- furyl methyl ketoneinvolving two green and environment friendly methods viz. biotransformation using Baker’s yeast as microbial catalyst in free as well as immobilized form and electrochemical method. Microbial transformation was carried out in water – isopropanol mixture (4:1) for selected substrates. The electrochemical reduction of these substrates was also carried out at constant current by using Stainless Steel Electrode (SS- 316). The reduction products were isolated and purified by chromatographic techniques and characterized on the basisof spectral analysis.

Analysis of methyl parathion in biological samples using thin layer chromatography.

Pesticides are major contaminating chemicals in agriculture environment and a hazard to exposed population. The pesticides form a strong class of environment pollutants, as they are sometimes nonbiodegradable, damaged not only the environment and agriculture but also have entered into the food chain thereby affecting health and development. Methyl parathion is a broad-spectrum organophosphorus insecticide generally used to control a variety of insects. The present study was planned to develop a new method for analysis of Methyl parathion in human blood samples using thin layer chromatography technique, which is simple and quick. Methyl Parathion was extracted from blood using solvent extraction methods and then identified on the TLC plates. For chromatographic separation, various binary and tertiary solvent systems were used and for detection on developed plates, palladium chloride reagent was used which successfully increased the sensitivity without dispensing with the simplicity of the method. Statistical analysis was performed on four solvent systems namely benzene: chloroform (80:20), hexane: carbontetrachloride (50:50), hexane: carbontetrachloride (20:80), hexane: propanol (20:80) which included the calculation of mean Rf value, value of standard deviation and coefficient of variance. It is evident from the statistical data that hexane: carbontetrachloride (50:50), hexane: carbon tetrachloride (20:80) is preferably good solvent systems for parathion identification by thin layer chromatography.

Biocatalytic and electrochemical reduction of selected phenyl alkanones with antibacterial activity of the corresponding phenyl alkanols.

This paper reports the production of some phenyl alkanols by the biocatalytic and electrochemical reduction of selected Phenyl alkanones viz. Propiophenone, Butyrophenone, and Valerophenone. Baker‘s yeast was used in its free as well as immobilized form for biocatalytic reduction. Substrates showed the higher conversion rate when the cells were used in immobilized form. The electrochemical behavior of substrates was investigated cyclic voltammetrically to explore electrochemical reduction as alternative synthetic route for the preparation of alcohols. Results obtained from cyclic voltammetric studies were used for establishing optimum conditions for electrochemical reduction which was then carried out galvanostatically using economically viable stainless steel (SS-316) electrodes. The reduction products were isolated and purified by chromatographic techniques and characterized on the basis of spectral analysis. The products thus obtained also exhibited significant antibacterial activity against four strains of bacteria viz. Staphylococcus aureus, Enterococcus faecaulis, Escherichia coli, Pseudomonas aeruginosa.

Synthesis, characterization and biocidal studies of some aromatic alcohols.

The synthesis and characterization of aromatic alcohols such as 1-(4-bromo phenyl) ethanol, 1-(4-Hydroxy-3-methoxyphenyl) ethanol, (4-Hydroxy-3-methoxy-benzyl alcohol) employing biotransformation (using whole cells of Baker’s Yeast in their free as well as immobilized form in mixtures of glycerol and water) and Electrochemical technique are reported. The electrochemical behavior of 4-bromoacetophenone, 4-Hydroxy-3-methoxyacetophenone, and 4-Hydroxy-3- methoxybenzaldehyde was analyzed using cyclic voltammetry at glassy carbon electrode (GCE) and constant current electrolysis. Effect of scan rate and pH on the reduction peaks has been calculated. The kinetic parameters were also calculated and the process was found to be diffusion controlled. The products obtained were purified & then characterized by spectroscopic techniques. All the compounds have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties. Biocatalytic and Electrochemical procedures were found to be more effective, safe, economical, environmental friendly, easy to handle. These green methodologies over conventional chemical methods provide new and improved synthetic routes to many valuable compounds.

Synthesis, characterisation and antimicrobial screening of some AZO compounds.

In this study, a series of azo compounds were synthesized in excellent yields via the diazotization of different aromatic amines followed by coupling with 2-naphthol. These compounds were characterized by elemental analysis, IR, 1H NMR and 13C NMR spectral techniques. The synthesized compounds have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties using disk diffusion method. The minimum inhibitory concentrations (MIC) were also determined by the broath microdilution technique. Some of the products exhibited comparable activity with known standard drugs at same concentration.

Eco friendly synthetic routes for the reduction of carbonyl and the substituted carbonyl compounds.

Incorporation of green methodology via biocatalytic and electrochemical steps using Baker’s Yeast and electrons as reducing agent respectively have been employed as a novel and efficient route to furnish relevent chiral building blocks for fine chemicals and pharmaceuticals. Reduction of selected ketones such as 2-methylcyclohexanone, 3-methylcyclohexanone, 4-methylcyclohexanone and ethyl-2-oxocyclopentanecarboxylate have been carried out by biotransformation (using whole cells of Baker’s Yeast in their free as well as immobilized form in mixtures of glycerol and water) and via electrochemical method to the corresponding alcohols. Optimum conditions for electrochemical reduction like solvent, supporting electrolyte, reduction potential and pH were determined at glassy carbon electrode employing cyclic voltammetric technique. The effect of scan rate, pH were also studied. The electrochemical reduction was carried out at constant current using stainless steel (SS-316) electrodes. The products obtained were purified & then the results of both reduction routes (biocatalytic & electrochemical) were compared and then characterized by spectroscopic techniques.

Synthesis, characterisation and biocidal studies of some hydroxamic acids.

The synthesis and characterization of a series of hydroxamic acids derived from benzoylation or acylation of substituted aryl hydroxylamine or hydroxylamine hydrochloride are reported. Elemental analysis, 1H NMR, 13C NMR, and IR spectral data of the compounds are discussed. All the compounds have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

Detection of endosulfan isomers and metabolites by GC-MS in the exhumed body of an infant.

Endosulfan is a broad spectrum, non-systemic contact, and alimentary insecticide. It is a mixture of two isomers. The analysis of this insecticide, its isomers a and b endosulfan and other metabolic fragments, especially endolactone and a chlorinated dicarboxylic product in the autopsy material of an infant was performed by GC-MS in an alleged case of infanticide related to a dowry demand case. It confirmed that the child had been poisoned with endosulfan prior to death. No autopsy material, except ash and bone were left of the mother, as her par-ents-in-law had cremated her body. A new method was developed on GC-MS for the detection of this insecticide, which can be highly useful for routine analysis of insecticides in forensic laboratories. A study of various metabolites of endosulfan was also performed which may be informative for metabolic pathways studies.